Drug interactions
Larotrectinib + Lurasidone
Severity: Minor
Larotrectinib and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and has been described as a modest CYP3A4 inhibitor. Lurasidone is a sensitive CYP3A4 substrate, so a small rise in its exposure is theoretically possible. Clinically meaningful effects have not been well established.
What this interaction means in plain words
Larotrectinib and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Lurasidone belongs to Central Nervous System.
Why it happens
Possible weak inhibition of CYP3A4 by larotrectinib reducing lurasidone clearance; this is not firmly established.
What to do
No routine dose change is needed. Watch for lurasidone adverse effects such as akathisia, sedation and parkinsonism when larotrectinib is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Lurasidone?
MediHelp rates the interaction as minor. Larotrectinib and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and has been described as a modest CYP3A4 inhibitor. Lurasidone is a sensitive CYP3A4 substrate, so a small rise in its exposure is theoretically possible. Clinically meaningful effects have not been well established.
How serious is the interaction between Larotrectinib and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for lurasidone adverse effects such as akathisia, sedation and parkinsonism when larotrectinib is started.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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