Drug interactions
Larotrectinib + Norethisterone
Severity: Minor
Larotrectinib and Norethisterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib may weakly inhibit CYP3A4, so an increase in norethisterone exposure is theoretical. Clinical importance is likely negligible.
What this interaction means in plain words
Larotrectinib and Norethisterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Norethisterone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 inhibition; not well established.
What to do
No routine adjustment; be aware if adverse effects increase.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Norethisterone?
MediHelp rates the interaction as minor. Larotrectinib and Norethisterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib may weakly inhibit CYP3A4, so an increase in norethisterone exposure is theoretical. Clinical importance is likely negligible.
How serious is the interaction between Larotrectinib and Norethisterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; be aware if adverse effects increase.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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