Drug interactions
Larotrectinib + Omeprazole
Severity: Minor
Larotrectinib and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a weak CYP3A4 inhibitor in vitro and could slightly increase omeprazole levels. Any effect is unlikely to matter clinically.
What this interaction means in plain words
Larotrectinib and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition may reduce omeprazole metabolism; not clinically established.
What to do
No routine adjustment is needed; monitor for omeprazole adverse effects only if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Omeprazole?
MediHelp rates the interaction as minor. Larotrectinib and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a weak CYP3A4 inhibitor in vitro and could slightly increase omeprazole levels. Any effect is unlikely to matter clinically.
How serious is the interaction between Larotrectinib and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for omeprazole adverse effects only if clinically indicated.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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