Drug interactions
Larotrectinib + Ribociclib
Severity: Moderate
Larotrectinib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may increase larotrectinib levels through CYP3A4 inhibition. This could increase neurotoxicity, hepatotoxicity and other adverse effects.
What this interaction means in plain words
Larotrectinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Larotrectinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4 metabolism of larotrectinib.
What to do
Monitor liver enzymes and neurologic symptoms. Reduce the larotrectinib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Ribociclib?
MediHelp rates the interaction as moderate. Larotrectinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib may increase larotrectinib levels through CYP3A4 inhibition. This could increase neurotoxicity, hepatotoxicity and other adverse effects.
How serious is the interaction between Larotrectinib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and neurologic symptoms. Reduce the larotrectinib dose if adverse effects occur.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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