Drug interactions
Larotrectinib + Saxagliptin
Severity: Minor
Larotrectinib and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a moderate CYP3A4 inhibitor and may raise saxagliptin levels. The increase is expected to be modest, and saxagliptin has a wide margin of safety.
What this interaction means in plain words
Larotrectinib and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Saxagliptin belongs to Endocrine.
Why it happens
CYP3A4 inhibition reduces conversion of saxagliptin to its active metabolite.
What to do
Usually no dose change is needed; monitor for saxagliptin adverse effects and glycemic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Saxagliptin?
MediHelp rates the interaction as minor. Larotrectinib and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a moderate CYP3A4 inhibitor and may raise saxagliptin levels. The increase is expected to be modest, and saxagliptin has a wide margin of safety.
How serious is the interaction between Larotrectinib and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no dose change is needed; monitor for saxagliptin adverse effects and glycemic response.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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