Drug interactions
Larotrectinib + Sirolimus
Severity: Moderate
Larotrectinib and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory potential, so a modest rise in sirolimus levels is possible. The clinical significance is uncertain but matters because of sirolimus's narrow therapeutic index.
What this interaction means in plain words
Larotrectinib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Larotrectinib belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Possible weak inhibition of CYP3A4-mediated sirolimus metabolism.
What to do
Monitor sirolimus trough levels after starting or stopping larotrectinib and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Larotrectinib and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Sirolimus?
MediHelp rates the interaction as moderate. Larotrectinib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Larotrectinib is a CYP3A4 substrate with weak inhibitory potential, so a modest rise in sirolimus levels is possible. The clinical significance is uncertain but matters because of sirolimus's narrow therapeutic index.
How serious is the interaction between Larotrectinib and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels after starting or stopping larotrectinib and adjust the dose accordingly.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
