Drug interactions
Larotrectinib + Solifenacin
Severity: Minor
Larotrectinib and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory potential, so any rise in solifenacin levels is likely small. Clinical significance is uncertain.
What this interaction means in plain words
Larotrectinib and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib; not well established clinically.
What to do
No routine dose adjustment is needed. Monitor for anticholinergic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Solifenacin
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Solifenacin?
MediHelp rates the interaction as minor. Larotrectinib and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory potential, so any rise in solifenacin levels is likely small. Clinical significance is uncertain.
How serious is the interaction between Larotrectinib and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Monitor for anticholinergic adverse effects.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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