Drug interactions
Lasmiditan + Ledipasvir-sofosbuvir
Severity: Minor
Lasmiditan and Ledipasvir-sofosbuvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits BCRP in vitro, and ledipasvir is a BCRP inhibitor and substrate as well as a P-gp substrate. Higher ledipasvir or sofosbuvir exposure is theoretically possible, but a clinically relevant effect has not been established.
What this interaction means in plain words
Lasmiditan and Ledipasvir-sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Ledipasvir-sofosbuvir belongs to Anti Virals.
Why it happens
Lasmiditan may inhibit BCRP-mediated efflux of ledipasvir/sofosbuvir, based on in vitro data.
What to do
No dose change is generally needed. Monitor for increased adverse effects such as headache and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as minor. Lasmiditan and Ledipasvir-sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits BCRP in vitro, and ledipasvir is a BCRP inhibitor and substrate as well as a P-gp substrate. Higher ledipasvir or sofosbuvir exposure is theoretically possible, but a clinically relevant effect has not been established.
How serious is the interaction between Lasmiditan and Ledipasvir-sofosbuvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for increased adverse effects such as headache and fatigue.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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