Drug interactions
Lasmiditan + Lorazepam
Severity: Moderate
Lasmiditan and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and somnolence and may impair driving. Lorazepam can add to these effects, increasing sedation and cognitive impairment.
What this interaction means in plain words
Lasmiditan and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; lasmiditan acts on 5-HT1F receptors while lorazepam potentiates GABA-A.
What to do
Monitor for excessive sedation and advise patients not to drive for at least 8 hours after lasmiditan, longer if lorazepam causes drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Lorazepam?
MediHelp rates the interaction as moderate. Lasmiditan and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and somnolence and may impair driving. Lorazepam can add to these effects, increasing sedation and cognitive impairment.
How serious is the interaction between Lasmiditan and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and advise patients not to drive for at least 8 hours after lasmiditan, longer if lorazepam causes drowsiness.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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