Drug interactions
Lasmiditan + Morphine
Severity: Moderate
Lasmiditan and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and may increase morphine exposure. The clinical impact is uncertain but increased opioid effects such as sedation are possible.
What this interaction means in plain words
Lasmiditan and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Inhibition of P-glycoprotein efflux transport, potentially increasing morphine absorption and brain penetration.
What to do
Monitor for excess sedation or respiratory depression and reduce the morphine dose if needed. Advise patients not to drive for at least 8 hours after lasmiditan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Morphine?
MediHelp rates the interaction as moderate. Lasmiditan and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein in vitro and may increase morphine exposure. The clinical impact is uncertain but increased opioid effects such as sedation are possible.
How serious is the interaction between Lasmiditan and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation or respiratory depression and reduce the morphine dose if needed. Advise patients not to drive for at least 8 hours after lasmiditan.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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