Drug interactions
Lasmiditan + Nilotinib
Severity: Moderate
Lasmiditan and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro, and nilotinib is a P-gp substrate, so nilotinib exposure may increase. Higher nilotinib levels could raise the risk of QT prolongation and other adverse effects.
What this interaction means in plain words
Lasmiditan and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by lasmiditan may increase nilotinib absorption.
What to do
Consider an alternative acute migraine therapy. If used together, monitor for nilotinib adverse effects and obtain an ECG if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Nilotinib?
MediHelp rates the interaction as moderate. Lasmiditan and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein in vitro, and nilotinib is a P-gp substrate, so nilotinib exposure may increase. Higher nilotinib levels could raise the risk of QT prolongation and other adverse effects.
How serious is the interaction between Lasmiditan and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative acute migraine therapy. If used together, monitor for nilotinib adverse effects and obtain an ECG if risk factors are present.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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