Drug interactions
Lasmiditan + Nortriptyline
Severity: Moderate
Lasmiditan and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan causes dizziness and sedation, which may be worsened by nortriptyline. Both have serotonergic activity in different ways, so a theoretical risk of serotonin syndrome exists, although lasmiditan is a 5-HT1F agonist.
What this interaction means in plain words
Lasmiditan and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS depression, with a theoretical serotonergic contribution.
What to do
Advise patients not to drive for at least 8 hours after lasmiditan. Monitor for serotonin toxicity symptoms and excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Nortriptyline?
MediHelp rates the interaction as moderate. Lasmiditan and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan causes dizziness and sedation, which may be worsened by nortriptyline. Both have serotonergic activity in different ways, so a theoretical risk of serotonin syndrome exists, although lasmiditan is a 5-HT1F agonist.
How serious is the interaction between Lasmiditan and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients not to drive for at least 8 hours after lasmiditan. Monitor for serotonin toxicity symptoms and excessive sedation.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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