Drug interactions
Lasmiditan + Pantoprazole
Severity: Minor
Lasmiditan and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits BCRP in vitro and could increase exposure to pantoprazole, a BCRP substrate. The clinical impact is likely small.
What this interaction means in plain words
Lasmiditan and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Inhibition of BCRP-mediated efflux of pantoprazole by lasmiditan.
What to do
No routine adjustment is needed; monitor for pantoprazole adverse effects if prolonged therapy is anticipated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Pantoprazole?
MediHelp rates the interaction as minor. Lasmiditan and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits BCRP in vitro and could increase exposure to pantoprazole, a BCRP substrate. The clinical impact is likely small.
How serious is the interaction between Lasmiditan and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for pantoprazole adverse effects if prolonged therapy is anticipated.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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