Drug interactions
Lasmiditan + Paroxetine
Severity: Moderate
Lasmiditan and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan is a 5-HT1F agonist that causes sedation and dizziness, and paroxetine may add CNS effects. Serotonin syndrome is a theoretical concern, though lasmiditan lacks vasoconstrictive 5-HT1B/1D activity.
What this interaction means in plain words
Lasmiditan and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Paroxetine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects and theoretical additive serotonergic activity.
What to do
Counsel patients not to drive for at least 8 hours after lasmiditan. Monitor for serotonin syndrome features if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Paroxetine?
MediHelp rates the interaction as moderate. Lasmiditan and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan is a 5-HT1F agonist that causes sedation and dizziness, and paroxetine may add CNS effects. Serotonin syndrome is a theoretical concern, though lasmiditan lacks vasoconstrictive 5-HT1B/1D activity.
How serious is the interaction between Lasmiditan and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to drive for at least 8 hours after lasmiditan. Monitor for serotonin syndrome features if symptoms arise.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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