Drug interactions
Lasmiditan + Pazopanib
Severity: Moderate
Lasmiditan and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein and BCRP in vitro, and pazopanib is a substrate of both transporters. Exposure to pazopanib could rise, increasing the risk of adverse effects.
What this interaction means in plain words
Lasmiditan and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Inhibition of intestinal P-gp and BCRP efflux by lasmiditan, increasing pazopanib absorption.
What to do
Consider an alternative acute migraine treatment during pazopanib therapy. If used, monitor for pazopanib toxicity including liver tests and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Pazopanib?
MediHelp rates the interaction as moderate. Lasmiditan and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein and BCRP in vitro, and pazopanib is a substrate of both transporters. Exposure to pazopanib could rise, increasing the risk of adverse effects.
How serious is the interaction between Lasmiditan and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative acute migraine treatment during pazopanib therapy. If used, monitor for pazopanib toxicity including liver tests and blood pressure.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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