Drug interactions
Lasmiditan + Phenelzine
Severity: Moderate
Lasmiditan and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan is a 5-HT1F agonist that causes sedation and dizziness, which may be additive with the CNS effects of an MAO inhibitor. A theoretical risk of serotonin toxicity also exists because of the MAO inhibitor's raised serotonin levels.
What this interaction means in plain words
Lasmiditan and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Additive CNS depression plus theoretical serotonergic excess from MAO inhibition.
What to do
Counsel the patient about sedation and advise against driving for at least 8 hours after a lasmiditan dose. Monitor for signs of serotonin syndrome such as agitation, tremor, hyperthermia and clonus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Phenelzine?
MediHelp rates the interaction as moderate. Lasmiditan and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan is a 5-HT1F agonist that causes sedation and dizziness, which may be additive with the CNS effects of an MAO inhibitor. A theoretical risk of serotonin toxicity also exists because of the MAO inhibitor's raised serotonin levels.
How serious is the interaction between Lasmiditan and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about sedation and advise against driving for at least 8 hours after a lasmiditan dose. Monitor for signs of serotonin syndrome such as agitation, tremor, hyperthermia and clonus.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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