Drug interactions
Lasmiditan + Quinine
Severity: Minor
Lasmiditan and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and could raise exposure to P-gp substrates. Quinine is a P-gp substrate, but the clinical effect is not well documented and is likely modest with intermittent migraine dosing.
What this interaction means in plain words
Lasmiditan and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
Why it happens
Possible inhibition of P-glycoprotein efflux of quinine.
What to do
No routine change needed. Watch for quinine adverse effects such as tinnitus or palpitations if used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Quinine?
MediHelp rates the interaction as minor. Lasmiditan and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-glycoprotein in vitro and could raise exposure to P-gp substrates. Quinine is a P-gp substrate, but the clinical effect is not well documented and is likely modest with intermittent migraine dosing.
How serious is the interaction between Lasmiditan and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed. Watch for quinine adverse effects such as tinnitus or palpitations if used together.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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