Drug interactions
Lasmiditan + Safinamide
Severity: Moderate
Lasmiditan and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can increase serotonergic activity, so using them together may raise the risk of serotonin syndrome. Symptoms include agitation, tremor, hyperreflexia, sweating and hyperthermia.
What this interaction means in plain words
Lasmiditan and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from MAO-B inhibition and lasmiditan's 5-HT1F agonism.
What to do
Counsel patients on symptoms of serotonin syndrome and monitor after dose changes. Stop lasmiditan and treat if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Safinamide?
MediHelp rates the interaction as moderate. Lasmiditan and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can increase serotonergic activity, so using them together may raise the risk of serotonin syndrome. Symptoms include agitation, tremor, hyperreflexia, sweating and hyperthermia.
How serious is the interaction between Lasmiditan and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on symptoms of serotonin syndrome and monitor after dose changes. Stop lasmiditan and treat if serotonin syndrome is suspected.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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