Drug interactions
Lasmiditan + Selegiline
Severity: Moderate
Lasmiditan and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise serotonergic activity, so using them together may increase the risk of serotonin syndrome. Lasmiditan is a 5-HT1F agonist and its serotonin syndrome risk is considered low, but selegiline is an MAO-B inhibitor that can become nonselective at higher doses.
What this interaction means in plain words
Lasmiditan and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Additive serotonergic effects, with possible loss of MAO-B selectivity at higher selegiline doses.
What to do
Monitor for agitation, tremor, hyperthermia, clonus and autonomic instability, particularly when starting treatment or raising doses. Stop lasmiditan and treat if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Selegiline?
MediHelp rates the interaction as moderate. Lasmiditan and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise serotonergic activity, so using them together may increase the risk of serotonin syndrome. Lasmiditan is a 5-HT1F agonist and its serotonin syndrome risk is considered low, but selegiline is an MAO-B inhibitor that can become nonselective at higher doses.
How serious is the interaction between Lasmiditan and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, clonus and autonomic instability, particularly when starting treatment or raising doses. Stop lasmiditan and treat if serotonin syndrome is suspected.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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