Drug interactions
Lasmiditan + Sulphasalazine
Severity: Moderate
Lasmiditan and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is a BCRP substrate, and lasmiditan inhibits BCRP in vitro. Higher sulfasalazine exposure may increase dose-related adverse effects such as nausea, headache and hematologic effects.
What this interaction means in plain words
Lasmiditan and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of intestinal BCRP efflux by lasmiditan, increasing sulfasalazine absorption.
What to do
Lasmiditan is used intermittently, so monitor for sulfasalazine adverse effects. Consider a lower sulfasalazine dose or an alternative migraine drug if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Sulphasalazine?
MediHelp rates the interaction as moderate. Lasmiditan and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfasalazine is a BCRP substrate, and lasmiditan inhibits BCRP in vitro. Higher sulfasalazine exposure may increase dose-related adverse effects such as nausea, headache and hematologic effects.
How serious is the interaction between Lasmiditan and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lasmiditan is used intermittently, so monitor for sulfasalazine adverse effects. Consider a lower sulfasalazine dose or an alternative migraine drug if effects emerge.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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