Drug interactions
Lasmiditan + Vincristine
Severity: Moderate
Lasmiditan and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro, which could increase exposure to vincristine. Any increase could worsen vincristine neurotoxicity, though clinical data are lacking. Lasmiditan is used for acute migraine so exposure is intermittent.
What this interaction means in plain words
Lasmiditan and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Vincristine belongs to Oncology.
Why it happens
Lasmiditan inhibits P-glycoprotein efflux, potentially raising vincristine concentrations.
What to do
Avoid lasmiditan on days around vincristine administration if an alternative migraine treatment is available. Monitor for neuropathy and gastrointestinal toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Vincristine?
MediHelp rates the interaction as moderate. Lasmiditan and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein in vitro, which could increase exposure to vincristine. Any increase could worsen vincristine neurotoxicity, though clinical data are lacking. Lasmiditan is used for acute migraine so exposure is intermittent.
How serious is the interaction between Lasmiditan and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid lasmiditan on days around vincristine administration if an alternative migraine treatment is available. Monitor for neuropathy and gastrointestinal toxicity.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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