Drug interactions
Latanoprost + Nepafenac
Severity: Minor
Latanoprost and Nepafenac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical NSAIDs given with prostaglandin analogues have been linked to variable effects on intraocular pressure. Nepafenac may blunt the pressure-lowering effect of latanoprost in some patients, but findings are inconsistent.
What this interaction means in plain words
Latanoprost and Nepafenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Latanoprost belongs to Miscellaneous; Nepafenac belongs to Musculoskeletal.
Why it happens
Possible pharmacodynamic interference of NSAID cyclooxygenase inhibition with prostaglandin analogue activity; the mechanism is not established.
What to do
Check intraocular pressure when nepafenac is started or stopped, and adjust glaucoma therapy if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Latanoprost
- Bimatoprost + Latanoprost Moderate
- Latanoprost + Latanoprostene bunod Moderate
- Latanoprost + Tafluprost Moderate
- Latanoprost + Travoprost Moderate
- Aspirin rectal + Latanoprost Minor
- Aspirin + Latanoprost Minor
Other interactions of Nepafenac
- Bimatoprost + Nepafenac Minor
- Nepafenac + Travoprost Minor
Frequently asked questions
Can I take Latanoprost with Nepafenac?
MediHelp rates the interaction as minor. Latanoprost and Nepafenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topical NSAIDs given with prostaglandin analogues have been linked to variable effects on intraocular pressure. Nepafenac may blunt the pressure-lowering effect of latanoprost in some patients, but findings are inconsistent.
How serious is the interaction between Latanoprost and Nepafenac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check intraocular pressure when nepafenac is started or stopped, and adjust glaucoma therapy if control changes.
What other medicines interact with Latanoprost?
MediHelp also lists interactions of Latanoprost with, for example, Bimatoprost, Latanoprostene bunod, Tafluprost. The full list is on the Latanoprost page.
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