Drug interactions
Ledipasvir-sofosbuvir + Magnesium oxide
Severity: Moderate
Ledipasvir-sofosbuvir and Magnesium oxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium oxide neutralizes gastric acid and raises gastric pH, and ledipasvir dissolves poorly at higher pH, so absorption may fall. This could reduce antiviral efficacy.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Magnesium oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ledipasvir-sofosbuvir belongs to Anti Virals; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH reduces the solubility and absorption of ledipasvir.
What to do
Separate antacid and ledipasvir/sofosbuvir doses by 4 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Magnesium oxide?
MediHelp rates the interaction as moderate. Ledipasvir-sofosbuvir and Magnesium oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium oxide neutralizes gastric acid and raises gastric pH, and ledipasvir dissolves poorly at higher pH, so absorption may fall. This could reduce antiviral efficacy.
How serious is the interaction between Ledipasvir-sofosbuvir and Magnesium oxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate antacid and ledipasvir/sofosbuvir doses by 4 hours.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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