Drug interactions
Ledipasvir-sofosbuvir + Rosuvastatin
Severity: Major
Ledipasvir-sofosbuvir and Rosuvastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir markedly increases rosuvastatin exposure, which raises the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ledipasvir-sofosbuvir belongs to Anti Virals; Rosuvastatin belongs to Cardiovascular.
Why it happens
Ledipasvir inhibits BCRP and OATP1B1/1B3, the transporters that handle rosuvastatin.
What to do
Avoid the combination if possible, or hold rosuvastatin during treatment; if continued, use the lowest dose and monitor for muscle symptoms and CK.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Rosuvastatin?
MediHelp rates the interaction as major. Ledipasvir-sofosbuvir and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ledipasvir markedly increases rosuvastatin exposure, which raises the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Ledipasvir-sofosbuvir and Rosuvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or hold rosuvastatin during treatment; if continued, use the lowest dose and monitor for muscle symptoms and CK.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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