Drug interactions
Ledipasvir-sofosbuvir + Tafamidis
Severity: Minor
Ledipasvir-sofosbuvir and Tafamidis: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis inhibits BCRP in vitro and could modestly increase exposure to ledipasvir and sofosbuvir. The clinical effect is likely small.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Tafamidis have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ledipasvir-sofosbuvir belongs to Anti Virals; Tafamidis belongs to Cardiovascular.
Why it happens
BCRP inhibition by tafamidis reduces intestinal efflux of ledipasvir/sofosbuvir.
What to do
No routine adjustment is needed; monitor for antiviral adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Atorvastatin + Tafamidis Moderate
- Methotrexate + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rivaroxaban + Tafamidis Moderate
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Tafamidis?
MediHelp rates the interaction as minor. Ledipasvir-sofosbuvir and Tafamidis have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tafamidis inhibits BCRP in vitro and could modestly increase exposure to ledipasvir and sofosbuvir. The clinical effect is likely small.
How serious is the interaction between Ledipasvir-sofosbuvir and Tafamidis?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for antiviral adverse effects.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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