Drug interactions
Lefamulin + Ribociclib
Severity: Major
Lefamulin and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin inhibits CYP3A4 and prolongs the QT interval, and ribociclib is a CYP3A4 substrate that also prolongs QT. Combining them raises ribociclib exposure and produces additive QTc prolongation, with risk of torsades de pointes. Lefamulin labeling advises against oral use with QT-prolonging CYP3A substrates.
What this interaction means in plain words
Lefamulin and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lefamulin belongs to Anti Bacterial; Ribociclib belongs to Oncology.
Why it happens
Lefamulin inhibits CYP3A4, raising ribociclib levels, plus additive QT prolongation.
What to do
Avoid the combination and choose another antibiotic. If unavoidable, correct potassium and magnesium and monitor ECG closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Ribociclib?
MediHelp rates the interaction as major. Lefamulin and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lefamulin inhibits CYP3A4 and prolongs the QT interval, and ribociclib is a CYP3A4 substrate that also prolongs QT. Combining them raises ribociclib exposure and produces additive QTc prolongation, with risk of torsades de pointes. Lefamulin labeling advises against oral use with QT-prolonging CYP3A substrates.
How serious is the interaction between Lefamulin and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antibiotic. If unavoidable, correct potassium and magnesium and monitor ECG closely.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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