Drug interactions
Lefamulin + Solifenacin
Severity: Major
Lefamulin and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin is a CYP3A4 inhibitor that increases exposure of CYP3A4 substrates, and solifenacin is both CYP3A4-metabolized and associated with QT prolongation at higher exposure. Together they may increase QT risk and anticholinergic effects.
What this interaction means in plain words
Lefamulin and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lefamulin belongs to Anti Bacterial; Solifenacin belongs to Genitourinary.
Why it happens
CYP3A4 inhibition raises solifenacin levels, adding to lefamulin's QT-prolonging effect.
What to do
Avoid oral lefamulin with solifenacin where possible; if needed, limit solifenacin to 5 mg daily and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Solifenacin?
MediHelp rates the interaction as major. Lefamulin and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lefamulin is a CYP3A4 inhibitor that increases exposure of CYP3A4 substrates, and solifenacin is both CYP3A4-metabolized and associated with QT prolongation at higher exposure. Together they may increase QT risk and anticholinergic effects.
How serious is the interaction between Lefamulin and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral lefamulin with solifenacin where possible; if needed, limit solifenacin to 5 mg daily and monitor ECG and electrolytes.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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