Drug interactions
Lemborexant + Maprotiline
Severity: Moderate
Lemborexant and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and combined use can increase somnolence and impair next-day alertness and psychomotor performance. Falls and driving impairment are the key risks.
What this interaction means in plain words
Lemborexant and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and the sedating effects of maprotiline.
What to do
Use the lowest effective lemborexant dose and warn the patient about driving and hazardous tasks. Reduce the dose if daytime sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Maprotiline?
MediHelp rates the interaction as moderate. Lemborexant and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and combined use can increase somnolence and impair next-day alertness and psychomotor performance. Falls and driving impairment are the key risks.
How serious is the interaction between Lemborexant and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and warn the patient about driving and hazardous tasks. Reduce the dose if daytime sedation occurs.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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