Drug interactions
Lemborexant + Metaxalone
Severity: Moderate
Lemborexant and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the central nervous system. Concurrent use can increase somnolence and next-day psychomotor impairment, raising the risk of falls and accidents.
What this interaction means in plain words
Lemborexant and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects of orexin receptor antagonism and metaxalone.
What to do
Use the lowest effective doses and review the need for both drugs. Counsel the patient about next-day impairment and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Metaxalone?
MediHelp rates the interaction as moderate. Lemborexant and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the central nervous system. Concurrent use can increase somnolence and next-day psychomotor impairment, raising the risk of falls and accidents.
How serious is the interaction between Lemborexant and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and review the need for both drugs. Counsel the patient about next-day impairment and driving.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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