Drug interactions
Lemborexant + Methoxsalen
Severity: Moderate
Lemborexant and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxsalen may increase lemborexant exposure, which can intensify somnolence and next-day impairment.
What this interaction means in plain words
Lemborexant and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Methoxsalen belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 metabolism of lemborexant by methoxsalen.
What to do
Limit lemborexant to the reduced maximum dose recommended with weak CYP3A4 inhibitors and counsel about morning drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Methoxsalen?
MediHelp rates the interaction as moderate. Lemborexant and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxsalen may increase lemborexant exposure, which can intensify somnolence and next-day impairment.
How serious is the interaction between Lemborexant and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the reduced maximum dose recommended with weak CYP3A4 inhibitors and counsel about morning drowsiness.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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