Drug interactions
Lemborexant + Mifepristone
Severity: Major
Lemborexant and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and can raise lemborexant concentrations. This may cause excessive sedation, next-day somnolence and impaired psychomotor performance.
What this interaction means in plain words
Lemborexant and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lemborexant belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lemborexant by mifepristone.
What to do
Avoid concurrent use and choose an alternative hypnotic that is not CYP3A4 dependent. If it must be used, monitor for next-day sedation and use the lowest effective lemborexant dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Mifepristone?
MediHelp rates the interaction as major. Lemborexant and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone inhibits CYP3A4 and can raise lemborexant concentrations. This may cause excessive sedation, next-day somnolence and impaired psychomotor performance.
How serious is the interaction between Lemborexant and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative hypnotic that is not CYP3A4 dependent. If it must be used, monitor for next-day sedation and use the lowest effective lemborexant dose.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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