Drug interactions
Lemborexant + Nicardipine
Severity: Moderate
Lemborexant and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is metabolized mainly by CYP3A4, and inhibitors increase its exposure. Nicardipine is a weak inhibitor, so next-day somnolence may be more likely.
What this interaction means in plain words
Lemborexant and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 metabolism of lemborexant by nicardipine.
What to do
Limit lemborexant to the lower labeled dose when used with a weak CYP3A4 inhibitor, and monitor for daytime somnolence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Nicardipine?
MediHelp rates the interaction as moderate. Lemborexant and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is metabolized mainly by CYP3A4, and inhibitors increase its exposure. Nicardipine is a weak inhibitor, so next-day somnolence may be more likely.
How serious is the interaction between Lemborexant and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the lower labeled dose when used with a weak CYP3A4 inhibitor, and monitor for daytime somnolence.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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