Drug interactions
Lemborexant + Quinidine
Severity: Moderate
Lemborexant and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine may raise lemborexant levels through CYP3A4 inhibition. This increases next-day somnolence and impairment.
What this interaction means in plain words
Lemborexant and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4 reduces lemborexant clearance.
What to do
Use the lower lemborexant nightly dose recommended with weak CYP3A4 inhibitors. Counsel about next-day drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Quinidine?
MediHelp rates the interaction as moderate. Lemborexant and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine may raise lemborexant levels through CYP3A4 inhibition. This increases next-day somnolence and impairment.
How serious is the interaction between Lemborexant and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lower lemborexant nightly dose recommended with weak CYP3A4 inhibitors. Counsel about next-day drowsiness.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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