Drug interactions
Lemborexant + Secobarbital
Severity: Major
Lemborexant and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may reduce lemborexant exposure through CYP3A4 induction, diminishing its effect. Both drugs also cause sedation, so additive CNS depression and next-day impairment may occur.
What this interaction means in plain words
Lemborexant and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lemborexant belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases lemborexant clearance, plus additive CNS depressant effects.
What to do
Avoid combination; use only one hypnotic agent. Strong CYP3A inducers should not be used with lemborexant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Secobarbital?
MediHelp rates the interaction as major. Lemborexant and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital may reduce lemborexant exposure through CYP3A4 induction, diminishing its effect. Both drugs also cause sedation, so additive CNS depression and next-day impairment may occur.
How serious is the interaction between Lemborexant and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination; use only one hypnotic agent. Strong CYP3A inducers should not be used with lemborexant.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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