Drug interactions
Lemborexant + Sertraline
Severity: Minor
Lemborexant and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is cleared by CYP3A4, and moderate or strong inhibitors raise its exposure and the risk of next-day somnolence. Sertraline is a weak CYP3A4 inhibitor, so the increase is likely small, but both drugs can cause CNS effects.
What this interaction means in plain words
Lemborexant and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lemborexant belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline may slightly raise lemborexant exposure, with some additive CNS effects.
What to do
Start lemborexant at the usual low dose and monitor for next-day drowsiness. Reduce the dose if impairment occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Sertraline?
MediHelp rates the interaction as minor. Lemborexant and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lemborexant is cleared by CYP3A4, and moderate or strong inhibitors raise its exposure and the risk of next-day somnolence. Sertraline is a weak CYP3A4 inhibitor, so the increase is likely small, but both drugs can cause CNS effects.
How serious is the interaction between Lemborexant and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start lemborexant at the usual low dose and monitor for next-day drowsiness. Reduce the dose if impairment occurs.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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