Drug interactions
Lemborexant + Thioridazine
Severity: Moderate
Lemborexant and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression. Together they can increase somnolence and impair next-day alertness and psychomotor performance.
What this interaction means in plain words
Lemborexant and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective lemborexant dose and counsel the patient about next-day drowsiness and driving. Reduce the dose if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Thioridazine?
MediHelp rates the interaction as moderate. Lemborexant and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression. Together they can increase somnolence and impair next-day alertness and psychomotor performance.
How serious is the interaction between Lemborexant and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and counsel the patient about next-day drowsiness and driving. Reduce the dose if sedation is excessive.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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