Drug interactions
Lemborexant + Ticagrelor
Severity: Moderate
Lemborexant and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor weakly inhibits CYP3A4 and may raise lemborexant levels. This may cause greater somnolence and next-day impairment.
What this interaction means in plain words
Lemborexant and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Ticagrelor belongs to Cardiovascular.
Why it happens
Ticagrelor weakly inhibits CYP3A4, reducing lemborexant clearance.
What to do
Use the lower maximum lemborexant dose per labeling for weak CYP3A4 inhibitors and counsel patients about next-day drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Ticagrelor?
MediHelp rates the interaction as moderate. Lemborexant and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticagrelor weakly inhibits CYP3A4 and may raise lemborexant levels. This may cause greater somnolence and next-day impairment.
How serious is the interaction between Lemborexant and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lower maximum lemborexant dose per labeling for weak CYP3A4 inhibitors and counsel patients about next-day drowsiness.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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