Drug interactions
Lemborexant + Verapamil
Severity: Major
Lemborexant and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil, a moderate CYP3A inhibitor, increases lemborexant exposure. This may cause excess somnolence and next-day impairment.
What this interaction means in plain words
Lemborexant and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lemborexant belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4-mediated metabolism of lemborexant.
What to do
Avoid the combination if possible by using another hypnotic. Labeling for moderate CYP3A inhibitors limits lemborexant to a lower maximum dose; monitor for daytime sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Verapamil?
MediHelp rates the interaction as major. Lemborexant and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Verapamil, a moderate CYP3A inhibitor, increases lemborexant exposure. This may cause excess somnolence and next-day impairment.
How serious is the interaction between Lemborexant and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible by using another hypnotic. Labeling for moderate CYP3A inhibitors limits lemborexant to a lower maximum dose; monitor for daytime sedation.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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