Drug interactions
Lemborexant + Zafirlukast
Severity: Moderate
Lemborexant and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast may weakly inhibit CYP3A4 and increase lemborexant exposure. This can cause greater next-day somnolence and impaired alertness or driving ability.
What this interaction means in plain words
Lemborexant and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast decreases lemborexant clearance.
What to do
Use the lower recommended lemborexant nightly dose if a weak CYP3A4 inhibitor is coadministered. Counsel patients about daytime drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Zafirlukast?
MediHelp rates the interaction as moderate. Lemborexant and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zafirlukast may weakly inhibit CYP3A4 and increase lemborexant exposure. This can cause greater next-day somnolence and impaired alertness or driving ability.
How serious is the interaction between Lemborexant and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lower recommended lemborexant nightly dose if a weak CYP3A4 inhibitor is coadministered. Counsel patients about daytime drowsiness.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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