Drug interactions
Lemborexant + Ziprasidone
Severity: Moderate
Lemborexant and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use may increase next-day drowsiness and impaired psychomotor performance. Ziprasidone is not a meaningful CYP3A4 inhibitor, so the pharmacodynamic effect is the main concern.
What this interaction means in plain words
Lemborexant and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective lemborexant dose and counsel about next-day impairment. Monitor for excessive sedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Ziprasidone?
MediHelp rates the interaction as moderate. Lemborexant and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use may increase next-day drowsiness and impaired psychomotor performance. Ziprasidone is not a meaningful CYP3A4 inhibitor, so the pharmacodynamic effect is the main concern.
How serious is the interaction between Lemborexant and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and counsel about next-day impairment. Monitor for excessive sedation and falls.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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