Drug interactions
Lenacapavir + Metaxalone
Severity: Moderate
Lenacapavir and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor, and its effect can persist for months after subcutaneous dosing. Metaxalone exposure may rise, increasing sedation and dizziness.
What this interaction means in plain words
Lenacapavir and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Metaxalone belongs to Musculoskeletal.
Why it happens
Lenacapavir inhibits CYP3A4, reducing metaxalone clearance.
What to do
Monitor for increased sedation and adverse effects and consider a lower metaxalone dose during and after lenacapavir therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Metaxalone?
MediHelp rates the interaction as moderate. Lenacapavir and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor, and its effect can persist for months after subcutaneous dosing. Metaxalone exposure may rise, increasing sedation and dizziness.
How serious is the interaction between Lenacapavir and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and adverse effects and consider a lower metaxalone dose during and after lenacapavir therapy.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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