Drug interactions
Lenacapavir + Mifepristone
Severity: Moderate
Lenacapavir and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir inhibits CYP3A4 and may increase mifepristone exposure, an effect that persists for months after the last subcutaneous dose. Higher mifepristone levels raise the risk of adverse effects including hypokalemia and QT prolongation.
What this interaction means in plain words
Lenacapavir and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Mifepristone belongs to Endocrine.
Why it happens
Lenacapavir inhibits CYP3A4, reducing mifepristone clearance.
What to do
Monitor for mifepristone adverse effects and potassium and ECG as appropriate. Use the lowest effective mifepristone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Mifepristone?
MediHelp rates the interaction as moderate. Lenacapavir and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir inhibits CYP3A4 and may increase mifepristone exposure, an effect that persists for months after the last subcutaneous dose. Higher mifepristone levels raise the risk of adverse effects including hypokalemia and QT prolongation.
How serious is the interaction between Lenacapavir and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mifepristone adverse effects and potassium and ECG as appropriate. Use the lowest effective mifepristone dose.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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