Drug interactions
Lenacapavir + Paclitaxel
Severity: Moderate
Lenacapavir and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor with a long half-life, so effects may persist for months after the last dose. Paclitaxel exposure may increase modestly through its CYP3A4 pathway.
What this interaction means in plain words
Lenacapavir and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Paclitaxel belongs to Oncology.
Why it happens
Lenacapavir inhibits CYP3A4, reducing the secondary metabolism of paclitaxel.
What to do
Monitor blood counts and neuropathy during paclitaxel therapy, including in patients who recently received lenacapavir injections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Paclitaxel?
MediHelp rates the interaction as moderate. Lenacapavir and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor with a long half-life, so effects may persist for months after the last dose. Paclitaxel exposure may increase modestly through its CYP3A4 pathway.
How serious is the interaction between Lenacapavir and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy during paclitaxel therapy, including in patients who recently received lenacapavir injections.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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