Drug interactions
Lenacapavir + Quetiapine
Severity: Moderate
Lenacapavir and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may raise quetiapine concentrations. This effect can persist for months after subcutaneous dosing because of its long half-life. Increased quetiapine exposure raises the risk of sedation, hypotension and QT prolongation.
What this interaction means in plain words
Lenacapavir and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Quetiapine belongs to Central Nervous System.
Why it happens
Lenacapavir inhibits CYP3A4, decreasing quetiapine metabolism.
What to do
Monitor for sedation, orthostatic hypotension and QT effects, and consider reducing the quetiapine dose, including when quetiapine is started within months after the last lenacapavir injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Quetiapine?
MediHelp rates the interaction as moderate. Lenacapavir and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may raise quetiapine concentrations. This effect can persist for months after subcutaneous dosing because of its long half-life. Increased quetiapine exposure raises the risk of sedation, hypotension and QT prolongation.
How serious is the interaction between Lenacapavir and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and QT effects, and consider reducing the quetiapine dose, including when quetiapine is started within months after the last lenacapavir injection.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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