Drug interactions
Lenacapavir + Regorafenib
Severity: Moderate
Lenacapavir and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may increase regorafenib concentrations. This could increase regorafenib toxicities such as hepatotoxicity and hypertension.
What this interaction means in plain words
Lenacapavir and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Regorafenib belongs to Oncology.
Why it happens
Lenacapavir inhibits CYP3A4-mediated metabolism of regorafenib.
What to do
Monitor liver function and blood pressure and adjust regorafenib dose as needed for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Regorafenib?
MediHelp rates the interaction as moderate. Lenacapavir and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may increase regorafenib concentrations. This could increase regorafenib toxicities such as hepatotoxicity and hypertension.
How serious is the interaction between Lenacapavir and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function and blood pressure and adjust regorafenib dose as needed for toxicity.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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