Drug interactions
Lenacapavir + Roflumilast
Severity: Moderate
Lenacapavir and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor, and the effect can persist for months after subcutaneous dosing. Roflumilast exposure may therefore rise, increasing PDE4-related adverse effects.
What this interaction means in plain words
Lenacapavir and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Roflumilast belongs to Respiratory.
Why it happens
Lenacapavir inhibits CYP3A4, decreasing roflumilast metabolism.
What to do
Monitor for diarrhea, weight loss, insomnia and mood changes, including when roflumilast is started months after the last lenacapavir injection. Consider stopping roflumilast if it is not tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Roflumilast?
MediHelp rates the interaction as moderate. Lenacapavir and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor, and the effect can persist for months after subcutaneous dosing. Roflumilast exposure may therefore rise, increasing PDE4-related adverse effects.
How serious is the interaction between Lenacapavir and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, weight loss, insomnia and mood changes, including when roflumilast is started months after the last lenacapavir injection. Consider stopping roflumilast if it is not tolerated.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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