Drug interactions
Lenacapavir + Tamsulosin
Severity: Moderate
Lenacapavir and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor whose effect persists for months after a subcutaneous dose. Tamsulosin exposure may rise, increasing the chance of orthostatic hypotension.
What this interaction means in plain words
Lenacapavir and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Tamsulosin belongs to Genitourinary.
Why it happens
Lenacapavir inhibits CYP3A4, decreasing tamsulosin clearance.
What to do
Monitor blood pressure and orthostatic symptoms, including for several months after the last lenacapavir injection. Reduce the tamsulosin dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Tamsulosin?
MediHelp rates the interaction as moderate. Lenacapavir and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor whose effect persists for months after a subcutaneous dose. Tamsulosin exposure may rise, increasing the chance of orthostatic hypotension.
How serious is the interaction between Lenacapavir and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, including for several months after the last lenacapavir injection. Reduce the tamsulosin dose if hypotension occurs.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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