Drug interactions
Lenacapavir + Ticagrelor
Severity: Moderate
Lenacapavir and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor, and its long-acting injectable form keeps this effect for months. Ticagrelor exposure may increase, with more bleeding and dyspnea.
What this interaction means in plain words
Lenacapavir and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Ticagrelor belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated ticagrelor metabolism by lenacapavir.
What to do
Monitor for bleeding and dyspnea, remembering that the inhibitory effect persists after the last injection. Consider an alternative antiplatelet if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Ticagrelor?
MediHelp rates the interaction as moderate. Lenacapavir and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor, and its long-acting injectable form keeps this effect for months. Ticagrelor exposure may increase, with more bleeding and dyspnea.
How serious is the interaction between Lenacapavir and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and dyspnea, remembering that the inhibitory effect persists after the last injection. Consider an alternative antiplatelet if bleeding occurs.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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