Drug interactions
Lenacapavir + Tinidazole
Severity: Minor
Lenacapavir and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor, and this effect persists for months after a subcutaneous dose. Tinidazole is partly cleared by CYP3A4, so its exposure may increase modestly.
What this interaction means in plain words
Lenacapavir and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lenacapavir belongs to Anti Virals; Tinidazole belongs to Anti Parasitic.
Why it happens
Lenacapavir inhibits CYP3A4, decreasing the metabolism of tinidazole.
What to do
Usually no adjustment is needed for a standard tinidazole course. Monitor for adverse effects such as nausea, dizziness or neurological symptoms during prolonged or repeated tinidazole therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Tinidazole?
MediHelp rates the interaction as minor. Lenacapavir and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A4 inhibitor, and this effect persists for months after a subcutaneous dose. Tinidazole is partly cleared by CYP3A4, so its exposure may increase modestly.
How serious is the interaction between Lenacapavir and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no adjustment is needed for a standard tinidazole course. Monitor for adverse effects such as nausea, dizziness or neurological symptoms during prolonged or repeated tinidazole therapy.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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