Drug interactions
Lenalidomide + Zidovudine
Severity: Moderate
Lenalidomide and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenalidomide commonly causes neutropenia and thrombocytopenia, and zidovudine adds marrow toxicity. Together they may produce more severe or prolonged cytopenias.
What this interaction means in plain words
Lenalidomide and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenalidomide belongs to Oncology; Zidovudine belongs to Anti Virals.
Why it happens
Additive myelosuppression (pharmacodynamic synergism).
What to do
Monitor complete blood counts frequently, and adjust lenalidomide dosing per labeling for cytopenias. Consider replacing zidovudine with a less myelosuppressive antiretroviral.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Lenalidomide
- Deferiprone + Lenalidomide Major
- Lenalidomide + Ropeginterferon alfa 2b Major
- Acalabrutinib + Lenalidomide Moderate
- Anakinra + Lenalidomide Moderate
- Cholera vaccine + Lenalidomide Moderate
- Denosumab + Lenalidomide Moderate
Frequently asked questions
Can I take Lenalidomide with Zidovudine?
MediHelp rates the interaction as moderate. Lenalidomide and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenalidomide commonly causes neutropenia and thrombocytopenia, and zidovudine adds marrow toxicity. Together they may produce more severe or prolonged cytopenias.
How serious is the interaction between Lenalidomide and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, and adjust lenalidomide dosing per labeling for cytopenias. Consider replacing zidovudine with a less myelosuppressive antiretroviral.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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